The present study deals with the potential of solid lipid nanoparticles intended for oral use in improving oral bioavailability of ketoprofen. The objective of the study was to develop and optimise the ketoprofen loaded solid lipid nanoparticles using solvent injection technique. The independent variables drug/lipid (Glyceryl monostearate) ratio and concentration of emulsifier (Poloxamer 407) were analysed using central composite design to study effect on response variables such as particle size, percent entrapment efficiency and percent cumulative drug release. In order to select the optimized formula nanoparticles were subjected to characterizations studies. The optimized batch showed average particle size of 158.8 nm with percent drug entrapment and cumulative drug release of 65.97% and 66.63% respectively. Optimised batch best fitted in korsmeyer-Peppas model of drug release kinetics. The optimised batch then filled in enteric coated capsule to facilitate complete dissolution of drug and to prevent the release of drug in stomach and associated unwanted side effects in gastrointestinal tract.
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